Publication – 2020 Oct 2.


Johann E GudjonssonLam C Tsoi, Feiyang Ma, Allison C Billi, K R van StraalenA R J V Vossen, H H van der Zee, Paul W Harms, Rachael Wasikowski, Christine M YeeSyed M RizviXianying Xing, Enze Xing, Olesya Plazyo, Chang ZengMatthew T PatrickMargaret M LoweRichard E Burney, Jeffrey H KozlowJill R Cherry-BukowiecYanyun Jiang, Joseph KirmaStephan WeidingerKelly C Cushing, Michael D RosenblumCeline Berthier, Amanda S MacLeod, John J Voorhees, Fei WenJ Michelle Kahlenberg, Emanual MaverakisRobert L ModlinErrol P Prens


Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease characterized by chronic abscess formation and development of multiple draining sinus tracts in the groin, axillae, and perineum. Using proteomic and transcriptomic approaches, we characterized the inflammatory responses in HS in depth, revealing immune responses centered on IFN-γ, IL-36, and TNF, with lesser contribution from IL-17A. We further identified B cells and plasma cells, with associated increases in immunoglobulin production and complement activation, as pivotal players in HS pathogenesis, with Bruton’s tyrosine kinase (BTK) and spleen tyrosine kinase (SYK) pathway activation as a central signal transduction network in HS. These data provide preclinical evidence to accelerate the path toward clinical trials targeting BTK and SYK signaling in moderate-to-severe HS.

PMID: 32853177    PMCID: PMC7566715    DOI: 10.1172/jci.insight.139930